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KMID : 0620920100420030187
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Experimental & Molecular Medicine
2010 Volume.42 No. 3 p.187 ~ p.194
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TGF-β-treated antigen presenting cells suppress collagen-induced arthritis through the promotion of Th2 responses
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Jung Sun-Do
Park Yoon-Kyung
Lee Hyun-Ji
Shin Jung-Hoon
Lee Gap-Ryol
Park Se-Ho
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Abstract
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Collagen-induced arthritis (CIA) is mediated by self-reactive CD4+ T cells that produce inflammatory cytokines. TGF-β2-treated tolerogenic antigen-presenting cells (Tol-APCs) are known to induce tolerance in various autoimmune diseases. In this study, we investigated whether collagen-specific Tol-APCs could induce suppression of CIA. We observed that Tol-APCs could suppress the development and severity of CIA and delay the onset of CIA. Treatment of Tol-APCs reduced the number of IFN-γ- and IL-17-producing CD4+ T cells and increased IL-4- and IL-5-producing CD4+ T cells upon collagen antigen stimulation in vitro. The suppression of CIA conferred by Tol-APCs correlated with their ability to selectively induce IL-10 production. We also observed that treatment of Tol-APCs inhibited not only cellular immune responses but also humoral immune responses in the process of CIA. Our results suggest that in vitro-generated Tol-APCs have potential therapeutic value for the treatment of rheumatoid arthritis as well as other autoimmune diseases.
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KEYWORD
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antigen-presenting cells, arthritis, experimental, autoimmune diseases, immune tolerance, Th1 cells, Th2 cells
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